Benefits of Innovative Compressed Gas-Powered Intranasal Drug Delivery Devices

OVERVIEW

Nelson Quintana discusses how Altaviz‘s AltaVISC delivery technology reaps the benefits of gas-powered drive systems over traditional spring-based systems for autoinjectors to offer a highly flexible platform technology for drug developers, allowing them to optimise their formulations within a wider range of delivery device specifications. 

THE NEXT-GENERATION DELIVERY SYSTEM: ALTAVISC

Patient-centric approaches are driving researchers to carefully balance the connected elements of drug concentration, viscosity and delivery volume in their ongoing efforts to optimise pharmacological dosing levels. To ascertain whether they can successfully accomplish their goals, they also need to assess the limitations of the current drug delivery landscape. The pursuit of more patient-friendly, longer-acting therapies is driving the development of treatments with increased delivery volumes and viscosities.

With higher viscosity and larger volumes, standard spring-powered autoinjectors must employ bigger springs to deliver their therapies in a reasonable time, which results in increased impact forces, leading to syringe breakage in conventional prefilled syringes (PFSs). Additionally, companies are being forced to gravitate towards the use of high-performance polymer syringes as a substitute to glass syringes due to the need for increased toughness. Doing so comes with significant costs and regulatory challenges, as this restriction presents a major obstacle in the development of novel medications….

FULL ARTICLE:  ONdrugDelivery
https://www.ondrugdelivery.com/altavisc-expanding-the-delivery-window-for-high-viscosity-high-volume-drugs/